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Bioscience Core Lab

Bioscience Core Lab

Offering cutting edge technologies and methods in genomics, proteomics and bioinformatics.

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The Bioscience Core Lab provides state-of-the-art facility to support genomic and proteomic studies. We offer to researchers our expertise ranging from project planning, experimental design, sample preparation, instrumentation, sequencing / mass spectrometry analysis, and downstream data analysis.

The Bioscience Core Lab offers three functional areas

The bioinformatics team operates in synergy with all other areas in Bioscience Core Lab.

Routinely, the bioinformatics team performs primary data analyses, quality control assessment and data management and distribution. We ensure computational and storage needs of Bioscience Core Lab instruments are met for today and tomorrow’s needs.

The team significantly contributes towards the planning and the establishing of new technologies, especially those relevant to high-throughput facilities.

At the other end, the bioinformatics team supports KAUST and within-the-Kingdom researchers by providing advice on experimental design and consultations for downstream analysis as well as bioinformatics training.

Where resources permit, the team also engages in scientific collaborations and early-access trials.

The proteomics lab is equipped with state-of-the-art mass spectrometers for global and targeted proteomics studies.

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Mass spectrometry-based proteomics can be used in qualitative and quantitative analysis of biological samples; to determine the protein content of cell extracts, organelles and tissues from different organisms.

In addition to the identification of proteins and the determination of their expression levels in different systems, the facility also provides comprehensive characterization of post-translational modifications and their relative quantitation.

We offer a growing range of capabilities; our staff are available for consultation on sample preparation and experimental design to provide the best analysis for each biological question. “One size doesn't fit all “.

In the Protein Expression area, we offer protein expression facilities for bacterial and mammalian cells, with Biosafety Level 2 Certification. The laboratory is well equipped for protein purification and protein-protein interaction studies. Our staff offer comprehensive training for researchers to be able to express and purify their proteins of interest.

 

For a listing of capabilities available in this area please click here

The genomics lab offers a wide range of applications covering third and next generation sequencing as well as capillary sequencing.

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Third generation sequencing (TGS) technologies are capable of generating very long reads on single DNA/RNA molecules. This is ideal for de-novo assembly, scaffolding, spanning repeats and complex structural rearrangements. It can also be used in studying different isoforms of full-length transcripts.

Next generation sequencing (NGS) provides high throughput short read sequencing capability to enable projects for re-sequencing, population genetics, transcriptomics and metagenomics, with protocols capable of handling minimal input of starting material. It can be coupled with single cell genomics technologies to study individually isolated subpopulations of cells.

KAUST Bioscience Core Lab is an approved PacBio Certified Service Provider

In addition, the laboratory is well equipped for capillary sequencing, low to high throughput qPCR and digital PCR, FACS analysis and cell sorting, and nucleic acid quantification.

For a listing of capabilities available in this area please click here